Do not use an American Express if you are a small business. You have no protection against anything as they are a charge card. You could literally lose ten of thousands of pounds from paying suppliers using American Express, and they will not assist you in recovering anything back. Stick with Visa or Mastercard who have a proper Section 75 protection clause.
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The American Express Company, also known as Amex, is an American multinational financial services corporation headquartered in Three World Financial Center in New York City.